National AIDS Research Institute, Pune.

Behavioral and biological assessment of HIV high-risk population in six HIV high prevalence states and five segments of national highways
Phase I Randomized, Placebo-Controlled, Double-Blind Dose-Escalation Trial to Evaluate the Safety and Immunogenicity of tgAAC09, a gag-PR-DRT AAV HIV Vaccine
Phase II Expanded Safety and Acceptability Study of the Vaginal Microbicide 1% Tenofovir Gel [HPTN 059]
Reddy Female Condom: Evaluation of Three Condom Shaft Lengths
Assessing the Vascular Changes occurring in the Cervix in relation to the Hormonal levels and Menstrual Cycle
Randomized Trial to Evaluate the Effectiveness of Antiretroviral Therapy plus HIV Primary Care versus HIV Primary Care Alone to Prevent the Sexual Transmission of HIV-1 in Sero-discordant Couples (HPTN 052 Study)
Annual Sentinel Surveillance for HIV infection

Phase IV, prospective, Randomized, Open Label Evaluation of The Efficacy of Once Daily Protease Inhibitor and Once-Daily Non-Nucleoside Reverse Transcriptase Inhibitor-Containing Therapy Combinations for Initial Treatment of HIV-1 Infected Individuals
Chemotherapy of tuberculosis in HIV infected patients: an evaluation of intermittent short course (RNTCP) regimens
National AIDS Control Organization Programme - NARI ART Link Center
Feasibility Study on Dementia - structured neurocognitive and neurological assessment of HIV infected individuals
Screening for Peripheral Neuropathy and Dementia in an HIV infected population using International HIV Dementia Scoring (IHDS)
Clinical Progression of HIV-infected Individuals

Genotypic & phenotypic characterization of HIV isolation
Anti-Retroviral Testing through genotypic characterization
Studies on Mother to Infant (MIT) Transmission
Studies on virus constructs expressing env, gag, pol, nef, tat and rev genes of HIV-I in modified Vaccinia Ankara

Subtyping of HIV-1 and detection of recombinants in India by high throughput screening

HIV-2 envelope gene cloning and sequencing from Indian patients
32 Mutation in CCR5 Coreceptor in Long term Non-Progressors and Exposed but Uninfected individuals
Neutralization epitope mapping in HIV-1 Envelope protein and characterization of escape mutants
Genetic Diversity and Molecular Characterization of HIV-1
Cellular Tropism of HIV-1 of Indian Clades in primary cell types and their sensitivities to novel inhibitors, chemokine antagonists and antibodies
Factors regulating slow and rapid progression of AIDS
Host and viral factors regulating transmission and pathogenesis of HIV-1 in HIV-associated neuropathogenesis and HIV-associated pulmonary tuberculosis
Trafficking of HIV-1 viral proteins, budding and assembly in primary cell types
Host and viral factors regulating transmission and pathogenesis of HIV-1 in HIV-associated neuropathogenesis and HIV-associated pulmonary tuberculosis
Testing of indigenous products to screen anti-HIV activities towards development of microbicides

Immunology:

Development of a candidate vaccine basedon multiple CTL epitopes for gag and env antigens from Indian HIV-1subtype C viruses
Immunological and virological characterization of early HIV infection
External quality assurance programme for NACO centers estimating CD4 count estimation in ART roll out programme
Interaction of dendritic cells and HIV
Characterization of HIV-specific Cytotoxic T Lymphocyte response

Serology:

Tests for HIV antibodies in the blood samples obtained from the patients who attended any of the nine clinics of the institute
Confirmation of HIV diagnosis of samples received from various organizations in and around Pune and other parts of Maharashtra state
Testing samples of foreign students admitted to Pune University
Testing of blood products for anti-HIV antibody received from the Drug Controller’s Office, Mumbai
Evaluation of commercial kits for detection of HIV antibody on receipt of request from the manufacturers

Microbiology:

Evaluating the essential service package (ESP) for sexually transmitted infections among sex workers in India.
Quinolone resistance mutations in Neisseria gonorrhea.
Role of induced sputum as a non-invasive tool for diagnosis of pulmonary infections in HIV positive patients.
Enteric pathogens in HIV infected individuals with diarrhea.
Study of virulence determinants of Candida species.
Isolation, identification and antibiotic sensitivity testing of microorganisms from stool, urine, sputum/oral swabs, and genital swabs specimens collected from patients (study related/referred) attending NARI clinics.
Mycobacterium tuberculosis testing of sputum/extra pulmonary specimens by ZN smear and culture for evaluation of efficacy of DOTS.
Serologic testing for syphilis (RPR/ TPHA), Hepatitis B surface antigen, HCV antibody, Cytomegalovirus (IgG/IgM), Toxoplasma (IgG/IgM), HSV-2 (IgG), Cryptococcal antigen for patients (study related/referred) attending NARI clinics.
Nucleic acid amplification assays for detection of sexually transmitted diseases (Neisseria gonorrhea, Chlamydia trachomatis, Genital ulcer diseases etc).
Evaluation of commercial kits for HCV antibody detection on request from UNOPS (United Nations Office for Project services).
External quality assurance programme for syphilis serology for Pathfinder International.

Clinical Pathology:

Fully automated hematology and biochemistry testing for patients (study related/referred) attending NARI clinics.
Urine analysis and urine pregnancy testing.
Cervical cytology screening.
In-built quality assurance program and College American Pathologists proficiency participation

Impact of Counseling on Behavior Change (Intra-mural activity)
Ancillary Social & Behavioral study in Clinical Trials & HIV vaccine trials.
Care & support studies among HIV infected individual.
Behavioral prevention & educational studies among adolescents
Community based studies to understand acceptability, feasibility & concern of clinical trial voluntery.
Psychometric studies to assess mental health needs of HIV infected individuals.
Consent comprehension studies (planned).